The Differences Between the Effect of Oral and Intraperitoneal Induction of Aluminum Chloride (AlCl3) on the Memory Function of White Rats (Rattus norvegicus strain wistar) Menopause Model

The decline in estrogen at menopause leads to a loss of neuroprotective function. One the effects is Alzheimer’s disease (AD), with clinical manifestations dementia, decreased memory function, language, thinking, and learning. pathology AD widely studied but not completely understood. Various animal models have been used able represent fully. This study aimed determine effect oral intraperitoneal induction aluminium chloride (AlCl3) on function menopausal model white rats (Rattus norvegicus strain wistar). 16 female rats, divided into four groups, namely negative control group (K1), ovariectomy (OVX, K2), OVX + AlCl.6H20 100 mg/kg BW orally (K3), AlCl3.6H20 group. 70 body weight intraperitoneally. was given for six weeks. In last five days, Morris water maze test carried out. From MANOVA test, p-value F values Pillai’s trace, Wilks‘ Lambda, Hotelling’a Trace, Roy’s Largest Root were < 0.05. Based post hoc Bonferroni fifth day trial, there significant difference between standard groups AlCl3 group, no groups. Conclusion: There Aluminum Chloride wistar) model.
 Keywords: menopause, disease,